When you work in the biopharmaceutical industry, you want to reduce time and bring efficiencies in manufacturing of biologic drugs from the clinic to market. 3M products combine our expertise in material science, filtration and polishing of proteins that provide solutions in upstream and downstream processing of biologics.
3M wants to help you do that. 3M™ Zeta Plus™ Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier, 3M™ LifeASSURE™ Filters and 3M™ Polisher ST are single-use products that enable robust purification platformability across diverse biopharmaceutical modalities, designed for all process stages from lab scale-up to manufacturing.
Versatile, adaptable 3M depth filters allow for effective clarification of biopharmaceutical manufacturing fluids. Our pharmaceutical-grade filters have high contaminant-holding capacity and provide economical filtration with reliable particle reduction.
Engineered for high capacity, fast flow rates, and including a product designed for reduction of negatively charged biological contaminants, such as endotoxin. A validated bacteria retentive membrane makes these filters ideal for biopharmaceutical sterilization.
Advanced anion exchange polymers, combined with fine fibre nonwovens and fine particle reduction membranes to create novel purification media. The result is a synthetic, single-use clarifying product that provides high purity.
With five standard types of activated carbon filters for a broad range of uses, 3M offers you a high degree of application flexibility. Our filter portfolio is designed for purification of a range of chemical and biological pharmaceutical fluids.
Introducing 3M™ Harvest RC: a new single-stage, single-use chromatographic clarification solution. It is the next generation in harvest and clarification technology and is designed as an efficient option to increase monoclonal antibody (mAb) yields while streamlining the upstream process by replacing the centrifuge and/or depth filtration process steps.
The goal of the polishing step is fast and efficient removal of residual contaminants in your process to achieve injectable product purity in the least number of polishing steps. 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses and other negatively charged contaminants in flowthrough polishing chromatography of biopharmaceutical process streams.
3M™ Polisher ST combines two complementary synthetic AEX functional medias: a quaternary ammonium (“Q”) functional nonwoven and a guanidiniumfunctional membrane. The Q-functional nonwoven provides reduction of turbidity (when present), DNA and endotoxin, as well as a portion of the product’s AEX capacity for HCP and virus reduction. The guanidinium functional membrane is salt tolerant and provides high HCP and virus reduction performance in a wider range of conditions compared to conventional Q-functional AEX resins.
3M™ Polisher ST eliminates the need for packing and cleaning validation and has 100X higher binding capacity to proteins, viruses, virus-like particles and other large complexes when compared to resins.
Marketplace demands continue to accelerate, challenging your manufacturing processes to run on time and on budget in order to meet market needs. Our single-stage technologies offer predictable scalability from discovery to commercial production, compressing multiple steps into one and helping to simplify your operations. Learn how 3M's fibre chromatography technology offers high performance single-stage clarification and purification solutions that help shorten your process train to reduce total manufacturing cost and increase speed to market.
This process train includes all 3M solutions. See other individual product solutions by clicking on the tabs below.
From cell culture clarification and soluble impurity reduction to mycoplasma reduction and final sterilizing filtration, our technologies deliver economical, robust solutions for a wide variety of applications within biopharmaceutical production.
Reduce microorganisms and control fine particles downstream.
Reduce particulates to help prevent plugging or fouling of chromatography columns.
Reduce DNA to target specification to help meet FDA requirements for protein therapeutic formulations.
Reduce cell debris from your process stream with a breadth of purification and depth filtration products.
The innovation and development in cell culture production has created additional complexities for the clarification process. 3M offers single-stage and single-use solutions to help simplify your process and increase manufacturing efficiency.CONNECT WITH A 3M ENGINEER