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Recombinant protein purification

Streamlined solutions for recombinant protein production.

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Product categories for biomanufacturing purification platforms

  • Five cylindrical depth filters in various sizes.

    Harvest and clarification depth filters

    Versatile, adaptable 3M depth filters allow for effective clarification of biopharmaceutical manufacturing fluids. Our pharmaceutical-grade filters have high contaminant-holding capacity and provide economical filtration with reliable particle reduction.

  • Four cylindrical membrane filters in various sizes.

    High-capacity membrane filters

    Engineered for high capacity, fast flow rates, and including a product designed for reduction of negatively charged biological contaminants, such as endotoxin. A validated bacteria retentive membrane makes these filters ideal for biopharmaceutical sterilization.

  • Various sizes and designs of chromatographic filters.

    Hybrid chromatographic purifiers

    Advanced anion exchange polymers, combined with fine fibre nonwovens and fine particle reduction membranes to create novel purification media. The result is a synthetic, single-use clarifying product that provides high purity.

  • Five black and one white activated carbon filters.

    High-purity activated carbon filters

    With five standard types of activated carbon filters for a broad range of uses, 3M offers you a high degree of application flexibility. Our filter portfolio is designed for purification of a range of chemical and biological pharmaceutical fluids.

Get help finding the optimal 3M purification solution.

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Bioprocessing reimagined

Get robust purification platformability across diverse biopharmaceutical modalities. Through chromotographic clarification of HCP, DNA and endotoxins, higher yield can be achieved. These solutions enable elimination and/or reduction in size of unit operations, leading to better overall process economics.

This process train includes all 3M solutions. See other individual product solutions by clicking on the tabs below.

3M Solutions

Eliminate the centrifuge

The combination of 3M™ Zeta Plus™ Series Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ LifeASSURE™ Membrane Filters may be a compelling alternative to a centrifuge-based Harvest-Clarification process.

Comprehensive options

Single-use, encapsulated devices for the potenial of cell mass removal with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.

Simplify the process

Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.

Quality and reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA Filter Capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

A clearer path

Provides higher purity Protein A eluant with reduced post-viral inactivation turbidity, eliminating the need for post-low pH viral inactivation (VI) depth filter.

Quality and reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA Filter Capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

3M™ Zeta Plus™ Depth Filter
Comprehensive options

Single-use, encapsulated devices for the potenial of cell mass removal with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.

Eliminate the centrifuge

3M™ Zeta Plus™ Depth Filter is an alternative solution that is capable of eliminating the centrifuge in your process.

Help protect your process

3M™ Zeta Plus™ Depth Filter can help protect your downstream membrane.

Comprehensive options

Wide selection of grades and charge level for small particle removal and membrane filter protection.

3M™ Emphaze™ AEX Hybrid Purifier
Eliminate the centrifuge

3M™ Emphaze™ Hybrid Purifier is an alternative solution, capable of eliminating the centrifuge in your process.

Simplify the process

Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.

A clearer path

Provides higher purity Protein A eluant with reduced post-viral inactivation turbidity, eliminating the need for post-low pH viral inactivation (VI) depth filter.


Featured applications

From cell culture clarification and soluble impurity reduction to mycoplasma reduction and final sterilizing filtration, our technologies deliver economical, robust solutions for a wide variety of applications within biopharmaceutical production.

  • A lab worker pouring liquid under a fumehood.

    Bioburden reduction

    Reduce microorganisms and control fine particles downstream.

  • A lab worker pipetting samples into a sample tray.

    Chromatography and column protection

    Reduce particulates to help prevent plugging or fouling of chromatography columns.

  • A scientist looking at a molecular model.

    DNA removal

    Reduce DNA to target specification to help meet FDA requirements for protein therapeutic formulations.

  • A scientist pipetting liquid into a beaker.

    Cell culture clarification

    Reduce cell debris from your process stream with a breadth of purification and depth filtration products.

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Need help streamlining your process?

3M experts will work with you to help find the optimal 3M purification and filtration solution for your application.

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